Thesis
Brenda R. Chen "Investigating mechanisms of hemodynamic control in the brain." Columbia University, 2012
Publications
Chen BR, Kozberg MG, Bouchard MB, Shaik MA, Hillman EMC, "A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain" Journal of the American Heart Association (2014)
Cayce JM, Bouchard MB, Chernov MM, Chen BR, Grosberg LE, Jansen D, Hillman EMC, "Calcium imaging of infrared-stimulated activity in rodent brain." Cell Calcium, in press (2014).
Kozberg MG, Chen BR, De Leo SE, Bouchard MB, Hillman EMC, “Resolving the transition from negative to positive BOLD in the developing brain.” PNAS Published ahead of print (2013).
Grosberg LE, Chen BR, Hillman EMC, "Simultaneous multi-plane in-vivo non-linear microscopy using spectral encoding", Optics Letters, 37(14) 2967-2969 (2012).
Muldoon, TJ, Burgess SA, Chen BR, Ratner D, Hillman EMC, "Analysis of skin lesions using laminar optical tomography". Biomed. Opt. Express, 3(7) 1701-1712 (2012).
Chen BR, Bouchard MB, McCaslin AFH, Burgess SA, Hillman EMC,"High-speed vascular dynamics of the hemodynamic response", Neuroimage, 54(2) 1021-1030 (2011).
McCaslin AFH, Chen BR, Radosevich AJ, Cauli B, Hillman EMC, "In-vivo 3D morphology of astrocyte-vasculature interactions in the somatosensory cortex: implications for neurovascular coupling", J Cereb Blood Flow Metab, 31, 795-806 (2011). (Feature Article and Cover)
Burgess SA, Ratner D, Chen BR, Hillman EMC, “Fiber-Optic and Articulating Arm Implementations of Laminar Optical Tomography for Clinical Applications” Biomed Opt Express, 1(3) 780-790 (2010)
Chen BR*, Bouchard MB*, Burgess SA, Hillman EMC, "Ultra-fast multispectral optical imaging of cortical oxygenation, blood flow and intracellular calcium dynamics", Optics Express 17(18) 15670-15678 (2009). * Equal contribution first authors. **Also selected to appear in the Virtual Journal of Biomedical Optics, 4(10) 15670 (2009).
Radosevich AJ, Bouchard MB, Burgess SA, Chen BR, Hillman EMC. "Hyper-spectral in-vivo two-photon microscopy of intrinsic contrast,", Optics Letters, 33(18) 2164-2166 (2008).
Oral Presentations
Chen BR, McCaslin AFH, L’Heurex B, Bouchard MB, Hillman EMC, “A multi-phase model of neurovascular coupling.” Advanced Studies Institute on Global Healthcare Challenges. Antalya, Turkey, 2011.
De Leo SE, Chen BR, Kozberg M, Gil O, Canoll P, Hillman EMC, ‘In-vivo optical imaging of glioma pathogenesis’, Brain 2011
Chen BR, Bouchard MB, Hillman EMC, “Optical imaging of neurovascular coupling in vivo.” 9th International Summer School on Biocomplexity: from Gene to System. Istanbul, Turkey 2010.
Selected Conference Abstracts
Chen BR, Bouchard MB, Castelli M, Hillman EMC, “A multi-phase model of neurovascular coupling”, Society for Neuroscience, Washington DC, 2011.
Timerman D, Chen BR, Rayshubskiy A, Kozberg M, Hillman EMC, “Optical imaging of resting state neurovascular coupling”, Society for Neuroscience, Washington DC, 2011.
Kozberg M, Chen BR, De Leo S, Hillman EMC, “In-vivo 3D morphology of cerebral vasculature during neonatal development”, Society for Neuroscience, Washington DC, 2011.
Cayce JM, Bouchard M, Chen BR, Jansen ED, Hillman EMC, Mahadevan-Jansen A. “Optical imaging of signals evoked by infrared neural stimulation of the rat brain”, Proc SPIE paper 7883G-146. 2011
Chen BR, McCaslin AFH, L’Heureux B, Bouchard MB, Hillman EMC, “Two-Photon Microscopy of Neurovascular Dynamics”, Society of General Physiologists, New Optical Methods in Cell Physiology, MBL Woods Hole, MA 2009 [Won $500 travel stipend]
Chen BR, Bouchard MB, McCaslin AFH, Hillman EMC, “Characterization of Cortical Vascular Compartment-Specific Hemodynamics during Somatosensory Stimulation”, Gordon Research Conference: Brain Energy, Metabolism & Blood Flow. Andover, NH 2010.
McCaslin AFH, Chen BR, Radosevich AJ, Hillman EMC, “In-vivo 3D morphology of astrocyte-vasculature interactions in the somatosensory cortex”, Society for Neuroscience Annual Meeting, Chicago IL 2009. [Selected as a ‘Media Highlight’ for the meeting]
Chen BR, Bouchard MB, McCaslin AFH, Hillman EMC, “Characterization of cortical vascular compartment-specific hemodynamics during somatosensory stimulation”, Society for Neuroscience Annual Meeting, Chicago IL 2009.
Grosberg LE, Radosevich AJ, Bouchard MB, Chen BR, Hillman EMC, “Hyperspectral Two-Photon Microscopy for 3D Instant Histology”, Engineering Conferences International meeting: Advances in Optics for Biotechnology, Medicine and Surgery XI. Burlington VT 2009
Chen BR, McCaslin AFH, Bouchard MB, Radosevich AJ, Burgess SA, Cauli B, Hillman EMC, “High-speed two-photon microscopy of reactive cortical cells in vivo”, Engineering Conferences International meeting: Advances in Optics for Biotechnology, Medicine and Surgery XI. Burlington VT 2009
Bouchard MB, Chen BR, Burgess SA, Hillman EMC, “Ultra-fast multiwavelength CCD-based optical imaging”, Engineering Conferences International meeting: Advances in Optics for Biotechnology, Medicine and Surgery XI. Burlington VT 2009.
Hillman EMC, Chen BR, Burgess SA, Radosevich AJ, Bouchard MB, Iranmahboob AK, Das A, Cauli B. “Multidimensional functional optical imaging of the brain”, [Invited, Best of the Topicals] In: Proceedings of OSA Frontiers in Optics (FiO) Rochester, NY 2008.
Hillman EMC, Chen BR, Burgess SA, Radosevich AJ, Bouchard MB, Iranmahboob AK, Das A, Cauli B “Multidimensional functional optical imaging of the brain”, [Invited] In: OSA Biomedical Topical Meetings, OSA Technical Digest, Optical Society of America, Washington DC, St Petersberg FL 2008
Hillman EMC, Levenson RM, Amoozegar CB, Chen BR, Burgess SA, Bouchard MB, “Dynamic molecular imaging of organ function”, Proceedings of the World Molecular Imaging Congress, Nice, France 2008.
Chen BR, Burgess SA, Bouchard MB, Cauli B, Hillman EMC, “Multi-scale in-vivo Optical Imaging of Neurovascular Coupling”, Gordon Research Conference: Brain Energy, Metabolism & Blood Flow. Andover, NH 2008.